"Tally thought of the lesions on Shay's brain, the tiny cancers or wounds or whatever they are that she didn't even know she had. They were in there somewhere changing her friend's thoughts, warping her feelings, gnawing at the roots of who she was."
It means that one of her best friends has some sort of brain disease and she doesn't know about and Tally can't do anything about it. So Tally just has to sit there and watch her friend get stupider and stupider.
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